Medical Sciences
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Fusobacterium nucleatum outer membrane vesicles activate autophagy to promote oral cancer metastasis
Published in ScienceDirect Publication: Journal of Advanced Research By Abstract AbstractIntroductionMetastasis is an important cause of high mortality and lethality of oral cancer. Fusobacterium nucleatum (Fn) can promote tumour metastasis. Outer membrane vesicles (OMVs) are secreted by Fn. However, the effects of Fn-derived extracellular vesicles […]
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Environmental viromes reveal global virosphere of deep-sea sediment RNA viruses
Published in ScienceDirect Publication: Journal of Advanced Research By Abstract Author links open overlay panelXinyi Zhang a, Haitao Wan a, Min Jin b, Liquan Huang a, Xiaobo Zhang aShow morehttps://doi.org/10.1016/j.jare.2023.04.003Get rights and contentHighlights•Global deep-sea sediment RNA viromes reveal 85,059 viral operational taxonomic units (vOTUs), the […]
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A novel tree shrew model of lipopolysaccharide-induced acute respiratory distress syndrome
Published in ScienceDirect Publication: Journal of Advanced Research By Abstract AbstractIntroductionAcute respiratory distress syndrome (ARDS) is a leading cause of respiratory failure, with substantial attributable morbidity and mortality. The small animal models that are currently used for ARDS do not fully manifest all of the […]
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Intricate confrontation: Research progress and application potential of TRIM family proteins in tumor immune escape
Published in ScienceDirect Publication: Journal of Advanced Research By Abstract AbbreviationsACTadoptive T-cell therapyAMLacute myelocytic leukemiaATMataxia telangiestasia mutatedBAMsBacillus Calmette-Guérin (BCG)-activated macrophagesBCGBacillus Calmette-GuérinCAFscancer-related fibroblastsCAR-Tschimeric antigen receptor T cellscGAS-STINGcyclic GMP-AMP synthase-stimulator of interferon genesCMLchronic myeloid leukemiaCTLA-4cytotoxic T lymphocyte-associated antigen-4DLBCLdiffuse large B-cell lymphomaDOCdedicator of cytokinesisEMTepithelial-mesenchymal transitionGMPSguanine monophosphate synthaseGSK-3βglycogen synthase […]
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Single-cell sequencing reveals the evolution of immune molecules across multiple vertebrate species
Published in ScienceDirect Publication: Journal of Advanced Research By Abstract Author links open overlay panelAnjun Jiao a b 1, Cangang Zhang a b 1, Xin Wang a b 1, Lina Sun a b 1, Haiyan Liu a b, Yanhong Su a b, Lei Lei a […]
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Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells – A potential contribution to the predictive, preventive, and personalized medicine
Published in ScienceDirect Publication: Journal of Advanced Research By Abstract Publication date: Available online 4 March 2023Source: Journal of Advanced ResearchAuthor(s): Alena Mazurakova, Lenka Koklesova, Sandra Hurta Csizmár, Marek Samec, Aranka Brockmueller, Miroslava Šudomová, Kamil Biringer, Erik Kudela, Martin Pec, Samson Mathews Samuel, Monika Kassayova, […]
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Large-scale genomic and transcriptomic analyses elucidate the genetic basis of high meat yield in chickens
Published in ScienceDirect Publication: Journal of Advanced Research By Abstract Author links open overlay panelXiaodong Tan a 1, Ranran Liu a 1, Di Zhao a, Zhengxiao He a, Wei Li a, Maiqing Zheng a, Qinghe Li a, Qiao Wang a, Dawei Liu b, Furong Feng […]
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Clinical evaluation of cell-free and cellular metagenomic next-generation sequencing of infected body fluids
Published in ScienceDirect Publication: Journal of Advanced Research By Abstract AbstractIntroductionPrevious studies have evaluated metagenomic next-generation sequencing (mNGS) of cell-free DNA (cfDNA) for pathogen detection in blood and body fluid samples. However, no study has assessed the diagnostic efficacy of mNGS using cellular DNA.ObjectivesThis is […]
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Strain specificity of lactobacilli with promoted colonization by galactooligosaccharides administration in protecting intestinal barriers during Salmonella infection
Published in ScienceDirect Publication: Journal of Advanced Research By Abstract Author links open overlay panelYujun Wu a, Xiangyu Zhang a, Xiaoyi Liu a, Yi Li a, Dandan Han a, Yu Pi a, Melanie A. Whitmore b, Xingmiao Lu c, Guolong Zhang b, Jinkai Zheng c, […]
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Characterization of brain resilience in Alzheimer’s disease using polygenic risk scores and further improvement by integrating mitochondria-associated loci
Published in ScienceDirect Publication: Journal of Advanced Research By Abstract Author links open overlay panelXuan Xu a, Hui Wang b c, David A. Bennett d e, Qing-Ye Zhang a, Xiang-Yu Meng a f, Hong-Yu Zhang aShow morehttps://doi.org/10.1016/j.jare.2023.03.002Get rights and contentHighlights•Characterizing the heterogeneity of individual cognitive […]
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